RT Journal Article
SR Electronic
T1 Clinicopathological and molecular study of penile melanoma
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 228
OP 231
DO 10.1136/jclinpath-2011-200344
VO 65
IS 3
A1 J D Oxley
A1 C Corbishley
A1 L Down
A1 N Watkin
A1 D Dickerson
A1 N A C S Wong
YR 2012
UL http://jcp.bmj.com/content/65/3/228.abstract
AB Aims To examine the clinicopathological features of a series of penile melanomas and screen for mutations in the BRAF and KIT genes, which are seen in melanomas from other sites.Methods and results 12 patients with penile melanoma were identified over a 10-year period in two supra-regional networks in the UK. The 2- and 5-year survival was 61% and 20%, respectively. Half the patients had lymph node involvement at presentation; this was a poor prognostic indicator. KIT exons 11, 13, 17 and 18, and BRAF codons 600 and 601 were analysed for mutations by Sanger sequencing and pyrosequencing, respectively. None of the tumours showed either KIT mutations or the BRAF V600E mutation.Conclusion Penile melanomas are extremely rare and have a similar prognosis to melanomas elsewhere, but they often present late, leading to a poor outcome. The mutations seen in melanomas from other sites appear to be rarely present in these tumours.