RT Journal Article
SR Electronic
T1 Increased plasma and salivary cortisol levels in patients with oral cancer and their association with clinical stage
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 934
OP 939
DO 10.1136/jclinpath-2012-200695
VO 65
IS 10
A1 Daniel Galera Bernabé
A1 Adriano Caires Tamae
A1 Glauco Issamu Miyahara
A1 Maria Lúcia Marçal Sundefeld
A1 Sandra Penha Oliveira
A1 Éder Ricardo Biasoli
YR 2012
UL http://jcp.bmj.com/content/65/10/934.abstract
AB Objectives Dysregulation of the hypothalamus–pituitary–adrenal axis has been observed in patients with cancer. This cross-sectional study investigated whether patients with oral and oropharyngeal squamous cell carcinoma (SCC) show changes in cortisol levels in saliva and plasma compared with three control groups, and evaluated its correlation with clinicopathological data.Methods Salivary and plasma cortisol levels of 34 patients with oral SCC were compared with hormonal levels of 17 oropharyngeal SCC patients, 17 oral leukoplakia patients, 27 smokers and/or drinkers and 25 healthy volunteers. Multivariate analysis was used to evaluate the impact of clinical variables on the cortisol levels.Results The plasma (p&lt;0.05) and salivary (p&lt;0.01) cortisol levels were significantly higher in patients with oral SCC compared with all groups. Patients with oropharyngeal SCC had higher levels of salivary cortisol compared with smokers and/or drinkers (p&lt;0.05) and patients with leukoplakia (p&lt;0.01). Patients with advanced-stage oral SCC showed significantly higher levels of cortisol than those in an initial clinical stage. Men with oral SCC had higher salivary cortisol levels than women (p&lt;0.05). Age, smoking, alcohol consumption, presence of teeth and awareness of cancer diagnosis had no significant effect on cortisol levels.Conclusions These results indicate a dysregulation of cortisol secretion in patients with oral cancer and suggest that this hormone can be a biomarker associated with the disease's clinical status.