TY - JOUR T1 - Expression of stanniocalcin-1 in culprit coronary plaques of patients with acute myocardial infarction or stable angina JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 787 LP - 791 DO - 10.1136/jclinpath-2013-201563 VL - 66 IS - 9 AU - Cheol Whan Lee AU - Ilseon Hwang AU - Chan-Sik Park AU - Hyangsin Lee AU - Duk-Woo Park AU - Soo-Jin Kang AU - Seung-Whan Lee AU - Young-Hak Kim AU - Seong-Wook Park AU - Seung-Jung Park Y1 - 2013/09/01 UR - http://jcp.bmj.com/content/66/9/787.abstract N2 - Background Stanniocalcin-1 (STC1) is involved in fundamental biological processes such as angiogenesis, inflammation and wound healing, but little is known about its expression in human coronary atherosclerotic plaques or its relationship to plaque instability. Objective STC1 expression was examined in the culprit coronary plaques of 70 patients with acute myocardial infarction (AMI; n=49) or stable angina (n=21) who underwent directional coronary atherectomy. Methods The specimens were stained with H&E, STC1-specific antibodies, and endothelial cells, macrophages and smooth muscle cell markers. Results The baseline characteristics of the two groups of patients were largely similar. CD31-immunopositive and CD68-immunopositive areas, indicative of the presence of endothelial cells and macrophages, respectively, were proportionately larger while areas immunopositive for α-actin, as a smooth muscle cell marker, were proportionately smaller in the AMI group than in the stable angina group. The proportion of STC1-immunopositive areas was significantly greater in the AMI group than in the stable angina group (20.0% (8.2–29.0%) vs 8.8% (3.9–19.4%), p=0.022). Areas positive for STC1 were independently correlated with those immunopositive for CD31 (r=0.42, p<0.001) and CD68 (r=0.40, p<0.001). STC1 immunoreactivity co-localised with CD31-immunopositive and CD68-immunopositive cells. Conclusions STC1 is differentially expressed in the culprit coronary plaques of patients with AMI versus those with stable angina. STC1 may play a role in plaque instability. ER -