RT Journal Article
SR Electronic
T1 Immunohistochemistry in the era of personalised medicine
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 58
OP 61
DO 10.1136/jclinpath-2012-201140
VO 66
IS 1
A1 Clare Margaret McCourt
A1 David Boyle
A1 Jacqueline James
A1 Manuel Salto-Tellez
YR 2013
UL http://jcp.bmj.com/content/66/1/58.abstract
AB Background Immunohistochemistry (IHC) plays a central role in the histopathological classification of diseases, including cancer. More recently, the importance of immunohistochemical staining is increasing. IHC usage in diagnostics is invaluable; however, the genetic and therapeutic significance of biomarker immunostaining has become equally relevant. Content In this article, we would like to analyse the three distinct roles of IHC and review their individual impacts on modern diagnostic pathology: (1) diagnostic IHC; (2) genetic IHC and (3) therapeutic IHC. Summary Thus, we will characterise the different analytical processes that are required in the three approaches to IHC usage stated above, as well as the clinical significance and overall importance in patient management. This will allow us to hypothesise on the most appropriate laboratory environment and detection methods for the future.