RT Journal Article
SR Electronic
T1 Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 350
OP 354
DO 10.1136/jclinpath-2013-201942
VO 67
IS 4
A1 Meng Huang
A1 Ai-Guo Tang
A1 Sa Mu
A1 Jing-Jing Yang
A1 Zhong-Yuan Xiang
A1 Bo Liu
A1 Jia-Jin Yang
YR 2014
UL http://jcp.bmj.com/content/67/4/350.abstract
AB Aim Serum pepsinogen (sPG) has been used to help in diagnosing atrophic corpus gastritis and in screening for gastric cancer non-invasively. There are as yet no reports on sPG reference intervals (RIs) with latex enhanced turbidimetric immunoassay (LIA). In this study, we established the RIs for sPG in a healthy Chinese population using LIA. Methods Serum PGI and PGII levels in a healthy population (aged 17–80 years) were measured simultaneously using LIA. RIs were determined following Clinical Laboratory and Standards Institute C28-A3 guidelines using a non-parametric method. Results 95% RIs in men (ng/mL) were: ≤40 years old, 25.53–100.76 for PGI and ≤24.42 for PGII; 41–50 years old, 26.62–124.74 for PGI and ≤26.81 for PGII; and 51–80 years old, 30.40–153.25 for PGI and ≤32.62 for PGII. Corresponding RIs for women (ng/mL) were: ≤40 years old, 21.20–87.44 for PGI and ≤25.53 for PGII; and 41–80 years, 26.40–127.46 for PGI and ≤30.18 for PGII. 95% RI for PGI/PGII in both men and women at any age was ≥2.51. Conclusions We established the RIs for sPG using LIA in a healthy Chinese population, which can provide a reference for clinical and laboratory studies.