PT  - JOURNAL ARTICLE
AU  - Sepe, Romina
AU  - Piscuoglio, Salvatore
AU  - Quintavalle, Cristina
AU  - Perrina, Valeria
AU  - Quagliata, Luca
AU  - Formisano, Umberto
AU  - Terracciano, Luigi Maria
AU  - Fusco, Alfredo
AU  - Pallante, Pierlorenzo
TI  - HMGA1 overexpression is associated with a particular subset of human breast carcinomas
AID  - 10.1136/jclinpath-2015-202907
DP  - 2016 Feb 01
TA  - Journal of Clinical Pathology
PG  - 117--121
VI  - 69
IP  - 2
4099  - http://jcp.bmj.com/content/69/2/117.short
4100  - http://jcp.bmj.com/content/69/2/117.full
SO  - J Clin Pathol2016 Feb 01; 69
AB  - Objectives Breast cancer represents the second leading cause of cancer mortality among American women and accounts for more than 40 000 deaths annually. High-mobility group A1 (HMGA1) expression has been implicated in the pathogenesis and progression of human malignant tumours, including breast carcinomas. The aim of this study was to evaluate HMGA1 detection as an indicator for the diagnosis and prognosis of human breast carcinoma.Methods HMGA1 expression has been analysed by immunohistochemistry in a large series of breast carcinoma resections (1338) combined on a tissue microarray mainly including the ductal carcinoma variant. The results were then correlated with clinicopathological parameters of patients.Results HMGA1 overexpression was found in the large majority of breast carcinoma samples and its overexpression positively correlated with HER-2/neu amplification and progesterone receptor, while a negative correlation was found with oestrogen receptor. Conversely, no HMGA1 expression was found in normal breast tissues.Conclusions The data reported here indicate that HMGA1 is overexpressed in human breast carcinomas and its levels are associated with a particular endocrine status.