TY - JOUR T1 - High Ki67 expression is an independent good prognostic marker in colorectal cancer JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 209 LP - 214 DO - 10.1136/jclinpath-2015-202985 VL - 69 IS - 3 AU - Nathaniel Melling AU - Charlotte Marie Kowitz AU - Ronald Simon AU - Carsten Bokemeyer AU - Luigi Terracciano AU - Guido Sauter AU - Jakob Robert Izbicki AU - Andreas Holger Marx Y1 - 2016/03/01 UR - http://jcp.bmj.com/content/69/3/209.abstract N2 - Aims To correlate Ki67 expression with outcome in colorectal cancer (CRC).Methods Ki67 labelling index (Ki67LI) was analysed by immunohistochemistry on a tissue microarray containing 1800 CRCs. The results were compared with clinicopathological and molecular parameters.Results Ki67LI was considered low in 26.3%, moderate in 56.7% and high in 17.0% of 1653 interpretable CRCs. High Ki67 expression was associated with low tumour stage (p<0.0001) and nodal status (p=0.0315), but not with tumour grade (p=0.8639), histological tumour type (p=0.1542) or tumour localisation, and was an independent prognosticator of favourable survival (p=0.0121). High Ki67 expression was also significantly associated with high-level nuclear β-catenin and p53 expression (p<0.0001 and p=0.0095, respectively).Conclusions In summary, our data show that high Ki67 expression in CRCs is associated with good clinical outcome. Ki67, p53 and β-catenin overexpression seem to be linked to CRC, and indicate a cellular state of high proliferative activity. Finally, our findings strongly argue for a clinical utility of Ki67 immunostaining as an independent prognostic biomarker in CRC. ER -