TY - JOUR T1 - Genetic mutations in accordance with a low malignant potential tumour are not demonstrated in clear cell papillary renal cell carcinoma JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 547 LP - 550 DO - 10.1136/jclinpath-2015-203565 VL - 69 IS - 6 AU - Maria Rosaria Raspollini AU - Francesca Castiglione AU - Liang Cheng AU - Rodolfo Montironi AU - Antonio Lopez-Beltran Y1 - 2016/06/01 UR - http://jcp.bmj.com/content/69/6/547.abstract N2 - Clear cell papillary renal cell carcinoma (CCPRCC) cases were evaluated for mutations on the following genes: KRAS, NRAS, BRAF, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET and EGFR. Four male and three female patients of age 42–74 years were evaluated. All cases were incidentally detected by ultrasound and ranged 1.8–3.5 cm. Microscopic examination showed variably tubulopapillary, tubular acinar, cystic architecture and the characteristic linear arrangement of nuclei. The cells were reactive with CK7 (strong), CA IX (cup-shape) and 34 β E12. CD10, AMACR/RACEMASE and GATA3 were negative. There were no mutations on any of the investigated genes. This preliminary observation supports the concept that CCPRCC might be indeed an indolent tumour worth it to be named as clear cell papillary neoplasm of low potential. ER -