RT Journal Article
SR Electronic
T1 Angiogenesis in melanoma: an update with a focus on current targeted therapies
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 472
OP 483
DO 10.1136/jclinpath-2015-203482
VO 69
IS 6
A1 George Jour
A1 Doina Ivan
A1 Phyu P Aung
YR 2016
UL http://jcp.bmj.com/content/69/6/472.abstract
AB Angiogenesis plays a crucial role in melanoma metastasis and progression. In recent years, numerous studies have investigated the prognostic and clinical significance of this phenomenon, and the development of molecular techniques has enabled us to achieve a better understanding of angiogenesis in melanoma. Herein, we review the current state of knowledge regarding angiogenesis in melanoma, including the pathophysiological, histological and immunohistochemical aspects of this phenomenon. We also review the molecular pathways involved in angiogenesis and the interplay between different components that might be manipulated in the future development of efficient targeted therapies. Recently developed targeted antiangiogenic therapies in clinical trials and included in the treatment of advanced-stage melanoma are also reviewed.