PT - JOURNAL ARTICLE AU - Clinton, Aoibhinn AU - McMullin, Mary Frances TI - The <em>Calreticulin</em> gene and myeloproliferative neoplasms AID - 10.1136/jclinpath-2016-203899 DP - 2016 Oct 01 TA - Journal of Clinical Pathology PG - 841--845 VI - 69 IP - 10 4099 - http://jcp.bmj.com/content/69/10/841.short 4100 - http://jcp.bmj.com/content/69/10/841.full SO - J Clin Pathol2016 Oct 01; 69 AB - The Philadelphia negative myeloproliferative neoplasms include polycythaemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF). Patients with these conditions were mainly thought to harbour JAK2V617F mutations or an Myeloproliferative leukaemia (MPL) substitution. In 2013, two revolutionary studies identified recurrent mutations in a gene that encodes the protein calreticulin (CALR). This mutation was detected in patients with PMF and ET with non-mutated JAK2 or MPL but was absent in patients with PV. The CALR gene encodes the calreticulin protein, which is a multifactorial protein, mainly located in the endoplasmic reticulum in chromosome 19 and regulates calcium homeostasis, chaperones and has also been implicated in multiple cellular processes including cell signalling, regulation of gene expression, cell adhesion, autoimmunity and apoptosis. Somatic 52 bp deletions and recurrent 52 bp insertion mutations in CALR were detected and all resulted in frameshift and clusters in exon 9 of the gene. This review will summarise the current knowledge on the CALR gene and mutation of the gene in pathological conditions and patient phenotypes.