@article {Kouba508, author = {Erik Kouba and Novae B Simper and Shaoxiong Chen and Sean R Williamson and David J Grignon and John N Eble and Gregory T MacLennan and Rodolfo Montironi and Antonio Lopez-Beltran and Adeboye O Osunkoya and Shaobo Zhang and Mingsheng Wang and Lisha Wang and Thu Tran and Robert E Emerson and Lee Ann Baldrige and M Francesca Monn and Konstantinos Linos and Liang Cheng}, title = {Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene}, volume = {70}, number = {6}, pages = {508--514}, year = {2017}, doi = {10.1136/jclinpath-2016-204088}, publisher = {BMJ Publishing Group}, abstract = {Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status.Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2.Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11{\textendash}64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58\% and 91\% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours.Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64\% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes.}, issn = {0021-9746}, URL = {https://jcp.bmj.com/content/70/6/508}, eprint = {https://jcp.bmj.com/content/70/6/508.full.pdf}, journal = {Journal of Clinical Pathology} }