TY - JOUR T1 - Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the <em>NAB2</em>-<em>STAT6</em> fusion gene JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 508 LP - 514 DO - 10.1136/jclinpath-2016-204088 VL - 70 IS - 6 AU - Erik Kouba AU - Novae B Simper AU - Shaoxiong Chen AU - Sean R Williamson AU - David J Grignon AU - John N Eble AU - Gregory T MacLennan AU - Rodolfo Montironi AU - Antonio Lopez-Beltran AU - Adeboye O Osunkoya AU - Shaobo Zhang AU - Mingsheng Wang AU - Lisha Wang AU - Thu Tran AU - Robert E Emerson AU - Lee Ann Baldrige AU - M Francesca Monn AU - Konstantinos Linos AU - Liang Cheng Y1 - 2017/06/01 UR - http://jcp.bmj.com/content/70/6/508.abstract N2 - Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status.Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2.Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11–64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours.Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes. ER -