%0 Journal Article %A Erik Kouba %A Novae B Simper %A Shaoxiong Chen %A Sean R Williamson %A David J Grignon %A John N Eble %A Gregory T MacLennan %A Rodolfo Montironi %A Antonio Lopez-Beltran %A Adeboye O Osunkoya %A Shaobo Zhang %A Mingsheng Wang %A Lisha Wang %A Thu Tran %A Robert E Emerson %A Lee Ann Baldrige %A M Francesca Monn %A Konstantinos Linos %A Liang Cheng %T Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene %D 2017 %R 10.1136/jclinpath-2016-204088 %J Journal of Clinical Pathology %P 508-514 %V 70 %N 6 %X Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status.Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2.Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11–64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours.Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes. %U https://jcp.bmj.com/content/jclinpath/70/6/508.full.pdf