%0 Journal Article
%A Erik Kouba
%A Novae B Simper
%A Shaoxiong Chen
%A Sean R Williamson
%A David J Grignon
%A John N Eble
%A Gregory T MacLennan
%A Rodolfo Montironi
%A Antonio Lopez-Beltran
%A Adeboye O Osunkoya
%A Shaobo Zhang
%A Mingsheng Wang
%A Lisha Wang
%A Thu Tran
%A Robert E Emerson
%A Lee Ann Baldrige
%A M Francesca Monn
%A Konstantinos Linos
%A Liang Cheng
%T Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene
%D 2017
%R 10.1136/jclinpath-2016-204088
%J Journal of Clinical Pathology
%P 508-514
%V 70
%N 6
%X Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status.Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2.Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11–64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours.Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes.
%U https://jcp.bmj.com/content/jclinpath/70/6/508.full.pdf