PT  - JOURNAL ARTICLE
AU  - Leiming Wang
AU  - Jian Sun
AU  - Zhuo Li
AU  - Li Chen
AU  - Yongjuan Fu
AU  - Lihong Zhao
AU  - Li Liu
AU  - Yukui Wei
AU  - Lianghong Teng
AU  - Dehong Lu
TI  - Gliosarcomas with the <em>BRAF</em> V600E mutation: a report of two cases and review of the literature
AID  - 10.1136/jclinpath-2017-204620
DP  - 2017 Dec 01
TA  - Journal of Clinical Pathology
PG  - 1079--1083
VI  - 70
IP  - 12
4099  - http://jcp.bmj.com/content/70/12/1079.short
4100  - http://jcp.bmj.com/content/70/12/1079.full
SO  - J Clin Pathol2017 Dec 01; 70
AB  - Gliosarcoma, which is regarded as a variant of glioblastoma, is a rare malignant neoplasm of the central nervous system. Both its sarcomatous component and glial component are reported to share significant clinical and genetic similarities. However, gliosarcomas are considered to be characterised by a lack of the BRAF V600E mutation. Here, we report two cases of gliosarcoma harbouring the BRAF V600E mutation, of which one case appears to have arisen de novo, while the other likely arose from ganglioglioma. Interestingly, the BRAF V600E mutation was detected only in the glial component in the first case, but was present in both the glial and the sarcomatous components in the recurrent gliosarcoma. Furthermore, the different mutation state of BRAF V600E in our two cases suggests that the malignant transformation of gliosarcoma might have different underlying genetic alterations and mechanisms in de novo versus recurrent gliosarcoma.