RT Journal Article
SR Electronic
T1 Unexplained abnormal liver function in patients with primary antibody deficiency: could it be chronic hepatitis E infection?
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 81
OP 83
DO 10.1136/jclinpath-2017-204627
VO 71
IS 1
A1 Mohamed, Omar E
A1 Jones, Julie
A1 Osman, Husam
A1 Huissoon, Aarnoud P
YR 2018
UL http://jcp.bmj.com/content/71/1/81.abstract
AB Data from recent studies suggest rising incidence rate of hepatitis E virus (HEV) infection in the UK. HEV infection may take a severe and persistent course in immunocompromised patients, including transplant recipients on immunosuppressives, patients with HIV, haematological malignancies and in idiopathic CD4+ T lymphocytopenia. The prevalence of HEV in primary antibody deficiency (PAD) disorders is still unknown. The aim of this study was to investigate HEV infection in 27 patients with PAD with unexplained, persistently elevated liver enzymes. Although all the 27 patients tested negative for HEV-RNA, we would still strongly recommend that HEV should be considered in any immunodeficient patient with impaired liver function.