RT Journal Article
SR Electronic
T1 Innovative haematological parameters for early diagnosis of sepsis in adult patients admitted in intensive care unit
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 330
OP 335
DO 10.1136/jclinpath-2017-204643
VO 71
IS 4
A1 Sabrina Buoro
A1 Barbara Manenti
A1 Michela Seghezzi
A1 Paola Dominoni
A1 Tiziano Barbui
A1 Arianna Ghirardi
A1 Alessandra Carobbio
A1 Gianmariano Marchesi
A1 Ivano Riva
A1 Alessandra Nasi
A1 Cosimo Ottomano
A1 Giuseppe Lippi
YR 2018
UL http://jcp.bmj.com/content/71/4/330.abstract
AB Aims This study was aimed to investigate the role of erythrocyte, platelet and reticulocyte (RET) parameters, measured by new haematological analyser Sysmex XN and C reactive protein (CRP), for early diagnosis of sepsis during intensive care unit (ICU) stay.Methods The study population consisted of 62 ICU patients, 21 of whom developed sepsis during ICU stay and 41 who did not. The performance for early diagnosing of sepsis was calculated as area under the curve (AUC) of receiver operating characteristics curves analysis.Results Compared with CRP (AUC 0.81), immature platelet fraction (IPF) (AUC 0.82) showed comparable efficiency for identifying the onset of sepsis. The association with the risk of developing sepsis during ICU stay was also assessed. One day before the onset of sepsis, a decreased of RET% was significantly associated with the risk of developing sepsis (OR=0.35, 95% CI 0.14 to 0.87), whereas an increased of IPF absolute value (IPF#) was significantly associated with the risk of developing sepsis (OR=1.13, 95% CI 1.03 to 1.24) 2 days before the onset of sepsis. The value of CRP was not predictive of sepsis at either time points.Conclusions IPF# and RET% may provide valuable clinical information for predicting the risk of developing sepsis, thus allowing early management of patients before the onset of clinically evident systemic infections.