RT Journal Article
SR Electronic
T1 Can reference images improve interobserver agreement in reporting liver fibrosis?
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 368
OP 371
DO 10.1136/jclinpath-2017-204760
VO 71
IS 4
A1 German, Alyn L
A1 Fleming, Kenneth
A1 Kaye, Philip
A1 Davies, Susan
A1 Goldin, Robert
A1 Hubscher, Stefan G
A1 Tiniakos, Dina
A1 McGregor, Angus
A1 Wyatt, Judith I
YR 2018
UL http://jcp.bmj.com/content/71/4/368.abstract
AB Staging of fibrosis in medical liver biopsies has inherent interobserver variability. There are a number of disease-specific scoring systems available. While recognising the importance of these scoring systems, there is scope to consider how concordance amongst histopathologists could be improved using a generic fibrosis staging system.Using virtual slides, we approached both specialist liver histopathologists and general histopathologists from the UK to assess the degree of fibrosis against a proposed four-tiered reporting system. Example reference images were then produced and distributed to the same responders who were asked to rate a second set of slides to assess if the use of reference images improved concordance between pathologists.The use of reference images eliminated spread across three categories (from 15% to 0%). Overall, agreement was already good; our study showed an improved agreement amongst all participants for percentage agreement (67.79% to 70.08%) and interobserver agreement improved (Fleiss’ Kappa 0.55 to 0.59).