TY - JOUR T1 - Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 879 LP - 884 DO - 10.1136/jclinpath-2018-205024 VL - 71 IS - 10 AU - Jakeline Ribeiro Barbosa AU - Vanessa Faria Cortes AU - Moyra Machado Portilho AU - Juliana Custódio Miguel AU - Vanessa Alves Marques AU - Cristianne Sousa Bezerra AU - Natalia Vasconcelos de Souza AU - Danielle Malta Lima AU - Jeová Keny Baima Colares AU - Lia Laura Lewis-Ximenez AU - Elisabeth Lampe AU - Livia Melo Villar Y1 - 2018/10/01 UR - http://jcp.bmj.com/content/71/10/879.abstract N2 - Aims Point of care testing (POCT) has been used for hepatitis B and C diagnosis in general population, but little is known about the influence of clinical conditions in the accuracy of these assays. This study aims to evaluate the performance of POCTs for detection of hepatitis B virus surface antigen (HBsAg) and antibodies to Hepatitis C Virus (anti-HCV) in Chronic Kidney Disease (CKD) patients.Methods A total of 286 subjects were included in this study. HBsAg and anti-HCV were detected using commercial EIAs and four POCTs: HBsAg (WAMA Imuno-Rápido HBsAg and VIKIA HBsAg) and anti-HCV (DOLES HCV teste rápido and WAMA Imuno-Rápido anti-HCV) in serum and whole blood.Results Using EIA, HBsAg and anti-HCV prevalence was 4.5% and 16.1% in CKD patients. HBsAg and anti-HCV POCTs had sensitivities from 92.3% to 100% and 84.8% to 89.1% while specificities were 99.3% to 100% and 99.2% to 99.6%, respectively. POCT using serum samples performed well compared with whole blood samples and true positive samples of POCTs had high optical density to cut-off (OD/CO) values compared with EIA.Conclusions This study demonstrates good performance of HBsAg and anti-HCV POCTs in CKD patients, especially in serum samples indicating low interference of this disease in the performance of these assays. POCTs could be an important tool for HBV and HCV screening in high-risk populations. ER -