PT  - JOURNAL ARTICLE
AU  - Andrew J Colebatch
AU  - Alexander Dobrovic
AU  - Wendy A Cooper
TI  - <em>TERT</em> gene: its function and dysregulation in cancer
AID  - 10.1136/jclinpath-2018-205653
DP  - 2019 Jan 28
TA  - Journal of Clinical Pathology
PG  - jclinpath-2018-205653
4099  - http://jcp.bmj.com/content/early/2019/01/28/jclinpath-2018-205653.short
4100  - http://jcp.bmj.com/content/early/2019/01/28/jclinpath-2018-205653.full
AB  - In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.