TY - JOUR T1 - Transformation of a splenic marginal zone lymphoma into classic Hodgkin lymphoma JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 391 LP - 392 DO - 10.1136/jclinpath-2018-205678 VL - 72 IS - 5 AU - Thomas Menter AU - Stefan Dirnhofer AU - Alexandar Tzankov Y1 - 2019/05/01 UR - http://jcp.bmj.com/content/72/5/391.abstract N2 - Sir,Transformation of marginal zone lymphoma (MZL) to aggressive lymphoma is considered a rare event with most cases evolving into diffuse large B-cell lymphoma (DLBCL).1 Here, we present a case of splenic MZL (sMZL) transforming into classic Hodgkin lymphoma (cHL).A patient, with a history of IgD-positive sMZL and treated with several cycles of rituximab and bendamustine and radiotherapy of the spleen, presented 2 years after initial diagnosis with bone pain due to osteolysis of the Os ilium. An imaging-guided bone biopsy revealed infiltrates of cHL (figure 1) while the patient still had residual histologically documented sMZL in the spleen … ER -