PT  - JOURNAL ARTICLE
AU  - Xu, Yiwang
AU  - Miremadi, Ahmad
AU  - Link, Alexander
AU  - Malfertheiner, Peter
AU  - Fitzgerald, Rebecca C
AU  - Bornschein, Jan
TI  - Feasibility of combined screening for upper gastrointestinal adenocarcinoma risk by serology and Cytosponge testing: the SUGAR study
AID  - 10.1136/jclinpath-2019-205700
DP  - 2019 Dec 01
TA  - Journal of Clinical Pathology
PG  - 825--829
VI  - 72
IP  - 12
4099  - http://jcp.bmj.com/content/72/12/825.short
4100  - http://jcp.bmj.com/content/72/12/825.full
SO  - J Clin Pathol2019 Dec 01; 72
AB  - Aims Aim was to assess the feasibility of serum markers to identify individuals at risk for gastro-oesophageal adenocarcinoma to reduce the number of individuals requiring invasive assessment by endoscopy.Methods Blood samples from 56 patients with Barrett’s oesophagus and 202 non-Barrett controls who previously took part in a trial assessing the accuracy of the Cytosponge for Barrett’s oesophagus were assessed for serum pepsinogen (PG) 1 and 2, gastrin-17, trefoil factor 3 (TFF3) and Helicobacter pylori infection.Results PG1 was pathological (<50 ng/mL) in 26 patients (10.1%), none of whom had Barrett’s oesophagus (p<0.001). Smoking and drinking had no influence on these results. Pathological PG1 was associated with stomach pain (p=0.029), disruption of sleep (p=0.027) and disruption of diet by symptoms (p=0.019). Serum TFF3 was not associated with any clinical parameter.Conclusions Assessment of serum PG1 could be combined with a test for Barrett’s oesophagus to identify additional patients requiring endoscopy.