TY - JOUR T1 - Somatic deletion of <em>KDM1A/LSD1</em> gene is associated to advanced colorectal cancer stages JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 107 LP - 111 DO - 10.1136/jclinpath-2019-206128 VL - 73 IS - 2 AU - Ruth Ramírez-Ramírez AU - Melva Gutiérrez-Angulo AU - Jorge Peregrina-Sandoval AU - José Miguel Moreno-Ortiz AU - Ramon Antonio Franco-Topete AU - Felipe de Jesús Cerda-Camacho AU - Maria de la Luz Ayala-Madrigal Y1 - 2020/02/01 UR - http://jcp.bmj.com/content/73/2/107.abstract N2 - Aims KDM1A/LSD1 and ZNF217 are involved in a protein complex that participates in transcriptional regulation. ZNF217 has been analysed in numerous cancers and its amplification has been associated with advanced stages of disease; however, a similar role for KDM1A/LSD1 has not been uncovered. In this study, we estimated the number of KDM1A/LSD1 and ZNF217 gene copies in tissue samples from patients diagnosed with colorectal cancer (CRC), as well as its association with clinicopathological features in patients with CRC.Methods Paraffin-embedded tumour samples from 50 patients with CRC with a histopathological diagnosis of CRC were included. The number of copies of KDM1A/LSD1 and ZNF217 genes was determined by fluorescence in situ hybridisation (FISH). We also analysed the association between copy numbers of selected genes and clinicopathological data based on multivariate analysis.Results Deletion of the KDM1A/LSD1 gene occurred in 19 samples (38%), whereas ZNF217 gene amplification was identified in 11 samples (22%). We found a significant association between lymph node metastasis or advanced tumour stage and KDM1A/LSD1 gene deletion (p value=0.0003 and p value=0.011, respectively).Conclusions KDM1A/LSD1 gene deletion could be considered a novel prognostic biomarker of late-stage CRC. ER -