TY - JOUR T1 - Thirty-six-year-old woman with a liver mass: diagnosis hidden in history JF - Journal of Clinical Pathology JO - J Clin Pathol SP - e7 LP - e7 DO - 10.1136/jclinpath-2019-206271 VL - 73 IS - 12 AU - Shoko Vos AU - Anna M Kamphuis AU - Lodewijk A A Brosens Y1 - 2020/12/01 UR - http://jcp.bmj.com/content/73/12/e7.abstract N2 - A 36-year-old woman presented with postprandial abdominal pain. Radiological assessment showed an irregular endoluminal mass in intrahepatic bile ducts and a separate mass in liver segment 8. A liver biopsy was performed. In addition, medical history revealed two skin excisions of lesions on the left thigh (at 24 years of age), and in the left popliteal space (at 30 years of age). Family history revealed several grandparents who died of cancer at older age (specific types not fully clear). Review the high quality, interactive digital Aperio slide of the liver biopsy and the skin excision (popliteal space) at http://virtualacp.com/JCPCases/jclinpath-2019-206271.R2_1/ and http://virtualacp.com/JCPCases/jclinpath-2019-206271.R2/ and consider your diagnosis.Intrahepatic cholangiocarcinoma and BAP1-inactivated melanocytic nevus/tumour in the context of BAP1 tumour predisposition syndrome.Intrahepatic cholangiocarcinoma and melanoma in the context of PALB2 tumour predisposition syndrome.Intrahepatic cholangiocarcinoma and Spitz nevus with a ROS1 fusion.Intrahepatic cholangiocarcinoma and Spitzoid melanoma in the context of Li Fraumeni syndrome.Metastastic pancreatic carcinoma and Spitzoid melanoma in the context of … ER -