RT Journal Article SR Electronic T1 Fibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 31 OP 35 DO 10.1136/jclinpath-2020-206574 VO 74 IS 1 A1 Tefera, Jonathan A1 Revzin, Margarita A1 Chapiro, Julius A1 Savic, Lynn Jeanette A1 Mulligan, David A1 Batra, Ramesh A1 Taddei, Tamar A1 Jain, Dhanpat A1 Zhang, Xuchen YR 2021 UL http://jcp.bmj.com/content/74/1/31.abstract AB Aims To establish and define a new, not previously reported hepatocellular carcinoma (HCC) variant, termed fibronodular HCC (FN-HCC).Methods We retrospectively reviewed 290 HCC cases and identified 29 FN-HCC and 24 scirrhous HCC (SCHCC). Clinical, pathological and radiological features of FN-HCC were reviewed and compared with 30 conventional HCCs (CV-HCC) and SC-HCC.Results FN-HCCs were more likely to arise in non-advanced fibrotic livers with lower advanced Barcelona Clinic Liver Cancer (BCLC) stage, had lower rates of progression and longer time to progression and were more likely to be surgically resected compared with CV-HCCs and SC-HCCs. Imaging analysis of FN-HCCs demonstrated higher rates of non-peripheral washout and a new distinct pattern of enhancement which is characterised by the presence of multiple rounded nodules within a lesion embedded in fibrotic-appearing parenchyma.Conclusions FN-HCC may represent a specific variant of HCC with distinct pathological, radiological and clinical features with potential ramifications for outcome.