@article {Fujikura244, author = {Kohei Fujikura and Daisuke Yamashita and Makoto Yoshida and Takayuki Ishikawa and Tomoo Itoh and Yukihiro Imai}, title = {Cytogenetic complexity and heterogeneity in intravascular lymphoma}, volume = {74}, number = {4}, pages = {244--250}, year = {2021}, doi = {10.1136/jclinpath-2020-206573}, publisher = {BMJ Publishing Group}, abstract = {Aims To characterise the karyotypic abnormalities and heterogeneities in intravascular lymphoma (IVL).Methods G-banded karyotyping was performed on biopsy specimens from a single-centre IVL cohort comprising intravascular large B-cell lymphoma (IVLBCL, n=12) and NK/T-cell lymphoma (IVNKTCL, n=1).Results Five IVLBCL cases and one IVNKTCL case (total 46\%) were found to have normal karyotypes, and the cytogenetic abnormalities observed in the other seven IVLBCL cases (54\%) were investigated further. These seven karyotypes were uniformly complex with an average of 13 aberrations. The seven cases all had abnormalities involving chromosome 6, with 57\% involving structural abnormalities at 6q13, and chromosome 8, with 43\% involving abnormalities at 8p11.2. In addition, 71\% had aberrations at 19q13. On average, 4.4 chromosomal gains and losses were detected per case. Cytogenetic heterogeneities were observed in six cases (86\%) and tetraploidy in three cases (43\%). There was no significant difference in progression-free survival (p=0.92) and overall survival (p=0.61) between the IVLBCL cases with complex and normal karyotypes.Conclusion Approximately half of IVLBCL cases had a highly heterogeneous pattern of karyotypes with different clonal numerical and structural chromosome aberrations.}, issn = {0021-9746}, URL = {https://jcp.bmj.com/content/74/4/244}, eprint = {https://jcp.bmj.com/content/74/4/244.full.pdf}, journal = {Journal of Clinical Pathology} }