RT Journal Article
SR Electronic
T1 Cytogenetic complexity and heterogeneity in intravascular lymphoma
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 244
OP 250
DO 10.1136/jclinpath-2020-206573
VO 74
IS 4
A1 Kohei Fujikura
A1 Daisuke Yamashita
A1 Makoto Yoshida
A1 Takayuki Ishikawa
A1 Tomoo Itoh
A1 Yukihiro Imai
YR 2021
UL http://jcp.bmj.com/content/74/4/244.abstract
AB Aims To characterise the karyotypic abnormalities and heterogeneities in intravascular lymphoma (IVL).Methods G-banded karyotyping was performed on biopsy specimens from a single-centre IVL cohort comprising intravascular large B-cell lymphoma (IVLBCL, n=12) and NK/T-cell lymphoma (IVNKTCL, n=1).Results Five IVLBCL cases and one IVNKTCL case (total 46%) were found to have normal karyotypes, and the cytogenetic abnormalities observed in the other seven IVLBCL cases (54%) were investigated further. These seven karyotypes were uniformly complex with an average of 13 aberrations. The seven cases all had abnormalities involving chromosome 6, with 57% involving structural abnormalities at 6q13, and chromosome 8, with 43% involving abnormalities at 8p11.2. In addition, 71% had aberrations at 19q13. On average, 4.4 chromosomal gains and losses were detected per case. Cytogenetic heterogeneities were observed in six cases (86%) and tetraploidy in three cases (43%). There was no significant difference in progression-free survival (p=0.92) and overall survival (p=0.61) between the IVLBCL cases with complex and normal karyotypes.Conclusion Approximately half of IVLBCL cases had a highly heterogeneous pattern of karyotypes with different clonal numerical and structural chromosome aberrations.