RT Journal Article
SR Electronic
T1 Clinicopathological characteristic of ciliated muconodular papillary tumour of the lung
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 128
OP 132
DO 10.1136/jclinpath-2020-207205
VO 75
IS 2
A1 Yang, Yong
A1 Xie, Xiaofeng
A1 Jiang, Gening
A1 Zhang, Liping
A1 Liu, Hongcheng
YR 2022
UL http://jcp.bmj.com/content/75/2/128.abstract
AB Aims Ciliated muconodular papillary tumour (CMPT) is a rare tumour characterised by tripartite cellular components of mucinous cells, ciliated columnar cells and basal cells with a predominantly papillary architecture. Its clinicopathological characteristics and treatment methods have not been fully elucidated.Methods Twenty-six patients with CMPT diagnosed and treated in our hospital were retrospectively analysed.Results The cohort was composed of 13 males and 13 females, with a mean age of 64.4±5.93 years. The diameter of the primary tumour ranged from 0.3 to 1.4 cm. The lesions appeared as subsolid nodules, ground-glass nodules and cavitary nodules under the CT scan. All the patients underwent surgical treatment and did not receive postoperative adjuvant therapy. All the CMPTs were diagnosed by immunohistochemistry and not by intraoperative frozen sections. Next-generation sequencing detection demonstrated EGFR, KRAS and BRAF mutations and ALK rearrangements in CMPTs. The follow-up duration ranged from 5 to 65 months, and no case of tumour recurrence was observed until the final follow-up.Conclusions The incidence of CMPT is low, and the prognosis is good. Immunohistochemistry is helpful for an accurate diagnosis of CMPT, while intraoperative frozen sections cannot fully guide the surgical method. Sublobectomy may be enough without adjuvant treatment. CMPTs exhibited a relatively high rate of driver gene mutations, while the mutation sites were not consistent with those in lung adenocarcinoma.Data are available upon reasonable request. Data are available from the authors.