TY - JOUR T1 - Preference of grade and lymphovascular invasion over invasive size measurement in stage I lung adenocarcinoma JF - Journal of Clinical Pathology JO - J Clin Pathol DO - 10.1136/jclinpath-2021-208053 SP - jclinpath-2021-208053 AU - Hiroe Itami AU - Takeshi Kawaguchi AU - Daiki Yoshikawa AU - Takashi Watanabe AU - Chiyoko Terada AU - Fumi Okada AU - Tomoko Uchiyama AU - Maiko Takeda AU - Eiwa Ishida AU - Yuko Nishimoto AU - Hiroshi Okada AU - Keiji Kushibe AU - Noriyoshi Sawabata AU - Chiho Ohbayashi Y1 - 2022/01/30 UR - http://jcp.bmj.com/content/early/2022/01/30/jclinpath-2021-208053.abstract N2 - Aims Although it is necessary to measure the invasive size of lung adenocarcinoma with a lepidic component, it is not uncommon to have trouble in measuring the invasive size of lung adenocarcinoma. This study examined whether there were other stronger prognostic factors than invasive size.Methods We characterised the clinicopathological features associated with recurrence-free survival (RFS) of 686 patients with the pathological stage (p-Stage) I lung adenocarcinoma. Moreover, we compared the area under the curve (AUC) values for recurrence between various combinations of pathological-baseline (age & sex & p-Stage based on invasive size) (B(i)) and several prognostic factors, and various combinations of p-baseline based on total tumour size (B(t)) and several prognostic factors.Results AUC showed no significant differences between B(i) & new International Association for the Study of Lung Cancer grade (G) or vascular invasion (V), and B(t) & G or V. AUC was the highest in B & G & lymphatic invasion (L) & V. RFS was significantly shorter in patients with G3 OR L(+) OR V(+) than in those with G≤2 AND L(-) AND V(-) in each p-Stage based on invasive size (p-Stage(i)) and p-Stage based on total tumour size (p-Stage(t)) (p<0.05), and there were no significant differences in RFS between each p-Stage(i) and p-Stage(t).Conclusions In any invasive size or total tumour size of p-Stage I lung adenocarcinoma, G, L and V are more powerful prognostic factors than the size criteria of p-Stage. Therefore, pathologists should focus on these pathological findings.All data relevant to the study are included in the article or uploaded as online supplemental information. ER -