PT  - JOURNAL ARTICLE
AU  - Jon Griffin
AU  - Yuqing Chen
AU  - James W F Catto
AU  - Sherif El-Khamisy
TI  - Gene of the month: NKX3.1
AID  - 10.1136/jclinpath-2021-208073
DP  - 2022 Jun 01
TA  - Journal of Clinical Pathology
PG  - 361--364
VI  - 75
IP  - 6
4099  - http://jcp.bmj.com/content/75/6/361.short
4100  - http://jcp.bmj.com/content/75/6/361.full
SO  - J Clin Pathol2022 Jun 01; 75
AB  - NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.