RT Journal Article
SR Electronic
T1 Correlation between circulating blood and microenvironment T lymphocytes in diffuse large B-cell lymphomas
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 493
OP 497
DO 10.1136/jclinpath-2020-207048
VO 75
IS 7
A1 Laddaga, Filomena Emanuela
A1 Ingravallo, Giuseppe
A1 Mestice, Anna
A1 Tamma, Roberto
A1 Perrone, Tommasina
A1 Maiorano, Eugenio
A1 Ribatti, Domenico
A1 Specchia, Giorgina
A1 Gaudio, Francesco
YR 2022
UL http://jcp.bmj.com/content/75/7/493.abstract
AB Aims Diffuse large B-cell lymphoma (DLBCL) is characterised by marked clinical and biological heterogeneity, attributable to the tumour cells and their microenvironment.Methods In this study, we investigated circulating subsets of blood lymphocytes and monocytes and their relationship with T cells in the tumour microenvironment (TME) in chemoresistant and chemosensitive patients with DLBCL.Results The study showed that (1) absolute lymphocyte count (ALC) and CD3+ and CD4+ cells were reduced in chemoresistant patients compared with chemosensitive patients; (2) lymphocyte:monocyte ratio (LMR) showed a positive correlation with peripheral blood CD3+ and CD4+ cells; (3) ALC, LMR, peripheral blood CD3+ and CD4+ cells showed a positive correlation with T cells in the TME.Conclusions Overall, these data suggest that DLBCL with high TME T cells display a pre-existing antitumour immune response. In the rituximab-containing regimen, TME T cells are stimulated further to participate in the immune response against lymphoma cells. In contrast, DLBCL lymphomas with low T-cell infiltration reflect the absence of a pre-existing antitumour immunity and have a lower likelihood of obtaining an optimal response to therapy.Data are available upon reasonable request.