RT Journal Article
SR Electronic
T1 Clinicopathological characteristics, genetics and prognosis of patients with myeloid sarcoma: a single-center study
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP jclinpath-2021-208000
DO 10.1136/jcp-2021-208000
A1 Derya Demir
A1 Mine Hekimgil
A1 Emin Karaca
A1 Yusuf Ulusoy
A1 Hamiyet Hekimci Özdemir
A1 Güray Saydam
A1 Burak Durmaz
A1 Haluk Akın
A1 Nazan Çetingül
A1 Murat Tombuloğlu
A1 Nazan Özsan
YR 2022
UL http://jcp.bmj.com/content/early/2022/08/04/jcp-2021-208000.abstract
AB Aim Myeloid sarcoma (MS) is a rare tumour comprising myeloid blasts occurring at an anatomical site other than the bone marrow. We sought to investigate both paediatric and adult patients with MS diagnosed at our institution and determine possible correlations among their clinicopathological, phenotypic, molecular and prognostic features.Methods This study retrospectively evaluated the data of 45 patients diagnosed with MS at Ege University Faculty of Medicine Hospital, Turkey, over a 17-year period.Results The male-to-female ratio was 1.5:1, and the median age was 39.12 years. The most commonly involved sites were the skin, lymph nodes, soft tissues and bone. Immunohistochemically, CD68-KP1 was the most commonly expressed marker, followed by CD33, myeloperoxidase, CD117, lysozyme, CD68-PGM1 and CD34. Of the patients, 26 (57.7%) presented with de novo MS, 7 (15.5%) had simultaneous acute myeloid leukaemia and 12 (26.8%) had a previous history of haematological disorders. Kaplan-Meier survival analysis revealed that the 2-year and 5-year overall survival (OS) rates were 46.4% and 39.8%, respectively; the median OS duration was 11 months. Increasing age had a negative prognostic relationship with survival (p = 0.04). Chromosomal abnormalities were detected in approximately 6/10 (60%) of paediatric patients and 6/9 (66.7%) of adult patients. t(8;21)(q22;q22) translocation was identified in 20% of paediatric patients.Conclusions MS diagnosis is usually challenging; an expanded immunohistochemical panel should be used for an accurate diagnosis. Although MS generally has a poor prognosis, increasing age appears to be associated with a worse outcome.All data relevant to the study are included in the article or uploaded as supplemental information. Data are available in online supplemental tables.