PT - JOURNAL ARTICLE AU - Chi, Zhikai AU - Balani, Jyoti AU - Gopal, Purva AU - Hammer, Suntrea AU - Xu, Jing AU - Peng, Lan TI - GATA3 positivity is associated with poor prognosis in patients with oesophageal squamous cell carcinoma AID - 10.1136/jclinpath-2021-208035 DP - 2023 Jul 01 TA - Journal of Clinical Pathology PG - 474--479 VI - 76 IP - 7 4099 - http://jcp.bmj.com/content/76/7/474.short 4100 - http://jcp.bmj.com/content/76/7/474.full SO - J Clin Pathol2023 Jul 01; 76 AB - Aims GATA-binding protein 3 (GATA3) is a zinc finger transcription factor with diverse biological functions and is an excellent diagnostic marker for breast and urothelial carcinoma. We aimed to study GATA3 expression in oesophageal squamous cell carcinoma (SCC) and its significance with respect to histological features, clinical parameters and overall survival.Methods We characterised GATA3 immunohistochemistry in 40 patients with oesophageal SCC. Electronic medical records were reviewed for clinical and follow-up information, as well as patient survival.Results Eleven (28%) oesophageal SCC were positive for GATA3. The predominant stain patterns were patchy, with either mild or moderate intensities. Patients with GATA3-positive tumours showed significantly shorter overall survival than those with GATA3-negative tumours (p=0.023, Kaplan-Meier survival analysis with log-rank test). In the multivariate Cox proportional hazards regression model, GATA3 positivity was an independent adverse prognostic factor for overall survival (p=0.019, HR 5.671). Surgery, definitive chemotherapy and/or radiotherapy, and initial clinical stage were confirmed as independent prognostic factors.Conclusion To the best of our knowledge, this is the first study to investigate the incidence of GATA3 positivity in oesophageal SCC and showed GATA3 positivity is associated with poor prognosis in oesophageal SCC.Data are available on reasonable request. The data used to support the findings of this study are available from the corresponding author on request.