Frequency of serological positivity in SLE
| Autoantibody target | % Positive at any stage of disease (any assay) | Possible clinical association (see text) |
|---|---|---|
| ACA, anticardiolipin antibody; dsDNA, double stranded DNA; ITP; idiopathic thrombocytopenic purpura; MCTD, mixed connective tissue disease; RNP, ribonuclear protein. | ||
| dsDNA | 30–70 | Nephritis, disease activity |
| Sm | 20–40 | Rarely seen outside SLE |
| RNP | 40–60 | MCTD/overlap features |
| Ro | 10–15 | Sjogren's/skin involvement/congenital heart block |
| Ribosomal P0, P1, P2 | 5–10 | Neuropsychiatric SLE, disease activity |
| Histone | 30 | Drug induced SLE, idiopathic SLE, disease activity |
| ACA | 40–50 | Risk of thrombotic complications/fetal loss/ITP |