Table 3

Frequency of serological positivity in SLE

Autoantibody target% Positive at any stage of disease (any assay)Possible clinical association (see text)
ACA, anticardiolipin antibody; dsDNA, double stranded DNA; ITP; idiopathic thrombocytopenic purpura; MCTD, mixed connective tissue disease; RNP, ribonuclear protein.
dsDNA30–70Nephritis, disease activity
Sm20–40Rarely seen outside SLE
RNP40–60MCTD/overlap features
Ro10–15Sjogren's/skin involvement/congenital heart block
Ribosomal P0, P1, P25–10Neuropsychiatric SLE, disease activity
Histone30Drug induced SLE, idiopathic SLE, disease activity
ACA40–50Risk of thrombotic complications/fetal loss/ITP