Relapse | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Site of origin | Colocalisation at 1st presentation | 1st | 2nd | 3rd | ||||||
Case | Age/sex | ALK | Site | ALK | Site | ALK | Site | ALK | Site | ALK |
Age is given in years. | ||||||||||
*This patient showed concurrent nodal (mesenteric and para-aortic) and intestinal (jejunal) disease. | ||||||||||
†Nodal involvement was not restricted to lymph nodes draining the extranodal tumour localisations. | ||||||||||
‡Locoregional lymph nodes. | ||||||||||
M, male; F, female; GI, gastrointestinal; LN, lymph node; Oes, oesophagus. | ||||||||||
Note: pattern of ALK staining (cytoplasmic and nuclear, or cytoplasmic only) as demonstrated by the primary biopsy is identical in biopsies from colocalisations or relapses of the same patient. | ||||||||||
Systemic (nodal) | ||||||||||
1 | 7/M | + | LN | + | ||||||
2 | 24/F | + | Skin | + | ||||||
3 | 24/M | + | Skin | + | LN | + | LN | + | ||
4 | 29/F | + | GI* | + | ||||||
5 | 52/M | − | Skin† | − | ||||||
6 | 18/M | − | Lung† | − | ||||||
7 | 68/F | − | Liver† | − | ||||||
8 | 55/M | − | LN | − | LN | − | ||||
9 | 27/M | − | LN | − | LN | − | ||||
10 | 63/M | − | Oes | − | ||||||
11 | 13/F | − | LN | − | ||||||
Gastrointestinal | ||||||||||
12 | 51/M | − | LN‡ | − | Lung | − | ||||
13 | 80/M | − | LN‡ | − | Bone | − | ||||
Nasal | ||||||||||
14 | 76/M | − | Testis | − | Bone | − | LN | − | ||
15 | 47/M | − | LN | − | Bone | − | LN | − | ||
Cutaneous | ||||||||||
16 | 32/M | − | Skin | − | ||||||
17 | 69/M | − | Skin | − | Skin | − | LN | − | ||
18 | 80/M | − | Skin | − | ||||||
19 | 69/F | − | LN | − | ||||||
20 | 29/F | − | Skin | − | Skin | − | Skin | − | ||
21 | 42/M | − | Skin | − | LN | − | ||||
22 | 40/M | − | Skin | − | Skin | − |