Table 2

ALK expression in ALCL specimens of patients with multiple biopsies or recurrent disease

Relapse
Site of originColocalisation at 1st presentation1st2nd3rd
CaseAge/sexALKSiteALKSiteALKSiteALKSiteALK
Age is given in years.
*This patient showed concurrent nodal (mesenteric and para-aortic) and intestinal (jejunal) disease.
†Nodal involvement was not restricted to lymph nodes draining the extranodal tumour localisations.
‡Locoregional lymph nodes.
M, male; F, female; GI, gastrointestinal; LN, lymph node; Oes, oesophagus.
Note: pattern of ALK staining (cytoplasmic and nuclear, or cytoplasmic only) as demonstrated by the primary biopsy is identical in biopsies from colocalisations or relapses of the same patient.
Systemic (nodal)
17/M+LN+
224/F+Skin+
324/M+Skin+LN+LN+
429/F+GI*+
552/MSkin†
618/MLung†
768/FLiver†
855/MLNLN
927/MLNLN
1063/MOes
1113/FLN
Gastrointestinal
1251/MLN‡Lung
1380/MLN‡Bone
Nasal
1476/MTestisBoneLN
1547/MLNBoneLN
Cutaneous
1632/MSkin
1769/MSkinSkinLN
1880/MSkin
1969/FLN
2029/FSkinSkinSkin
2142/MSkinLN
2240/MSkinSkin