Association of argyrophilic nucleolar organiser region (AgNOR) count with clinical and biological parameters at diagnosis
| Parameter | N | % | AgNOR count (mean (SD)) | Significance |
|---|---|---|---|---|
| *Cytoplasmic κ chain only. | ||||
| †Overall range (median): serum IgG, 18.5–90.1 g/l (57.8); serum IgA, 10.5–61.8 g/l (28.65); urinary light chain, 2.4–13.7 g/24 hours (9.4). | ||||
| ‡IgG, ≤ 60 g/l; IgA, ≤ 40 g/l; urinary light chain ≤8 g/24 hours. | ||||
| ¶Total 53 (IgD and non-secretory patients not included). | ||||
| FMean (SD) are not given for distributions significantly deviating from normal. | ||||
| β2m, β2 microglobulin; CRP, C reactive protein; LDH, lactate dehydrogenase; NS, not significant. | ||||
| Stage | ||||
| I | 8 | 14.5 | 3.09 (1.19) | p < 0.005 |
| II | 9 | 16.4 | 3.80 (1.53) | |
| III | 38 | 69.1 | 5.28 (1.79) | |
| Substage | ||||
| A | 48 | 87.3 | 4.73 (1.93) | NS |
| B | 7 | 12.7 | 4.60 (1.42) | |
| Heavy chain isotype | ||||
| γ | 35 | 63.6 | 4.79 (1.79) | NS |
| α | 14 | 25.5 | 3.99 (1.85) | |
| δ | 1 | 1.8 | 7.3 | |
| Bence-Jones | 4 | 7.3 | 6.38 (1.55) | |
| Non-secretory* | 1 | 1.8 | 3.2 | |
| Light chain isotype | ||||
| κ | 32 | 58.2 | 4.89 (1.87) | NS |
| λ | 23 | 41.8 | 4.50 (1.87) | |
| Haemoglobin (g/l) (overall range, 68–160; median, 107, mean, 110.7; SD, 19.7) | ||||
| ≤ 105 | 26 | 47.3 | 5.16 (2.11) | NS |
| > 105 | 29 | 52.7 | 4.32 (1.54) | |
| Calcium (mg/l) (overall range, 78–127; median, 99; mean, 98.5; SD, 9.8) | ||||
| ≤ 100 | 36 | 65.5 | 4.47 (1.79) | NS |
| > 100 | 19 | 34.5 | 5.19 (1.96) | |
| Skeletal lesions scale | ||||
| 0 | 9 | 16.4 | 3.91 (1.89) | NS |
| 1 | 4 | 7.3 | 4.48 (1.72) | |
| 2 | 14 | 25.4 | 4.76 (1.95) | |
| 3 | 28 | 50.9 | 4.99 (1.86) | |
| M protein concentration† | ||||
| Low‡ | 34¶ | 64.2 | 4.01 (1.52) | p < 0.001 |
| High | 19 | 35.8 | 5.92 (1.80) | |
| Platelet count (×109/l) (overall range, 75–340; median, 200)F | ||||
| ≤ 150 | 11 | 20.0 | 4.67 (1.46) | NS |
| > 150 | 44 | 80.0 | 4.73 (1.97) | |
| Albumin (g/l) (overall range, 21–48; median, 35; mean, 34.9; SD, 6.8) | ||||
| ≤ 30 | 17 | 30.9 | 4.95 (1.85) | NS |
| > 30 | 38 | 69.1 | 4.61 (1.88) | |
| LDH (U/l) (overall range, 52–854; median, 127)F | ||||
| ≤ 180 | 46 | 83.6 | 4.89 (1.82) | NS |
| > 180 | 9 | 16.4 | 4.31 (2.32) | |
| Marrow infiltration rate (%) (overall range, 15–95; median, 50)F | ||||
| ≤ 30 | 18 | 32.7 | 4.61 (1.37) | NS |
| 31–50 | 15 | 27.3 | 3.81 (1.69) | |
| > 50 | 22 | 40.0 | 5.42 (2.10) | |
| Histological grade | ||||
| I | 29 | 52.7 | 4.87 (1.78) | NS |
| II | 18 | 32.7 | 4.58 (1.88) | |
| III | 8 | 14.6 | 4.46 (2.30) | |
| β2m (mg/l) (overall range, 0.9–11.3; median, 3.0)F | ||||
| ≤ 6.0 | 39 | 70.9 | 4.68 (1.83) | NS |
| > 6.0 | 16 | 29.1 | 4.80 (2.02) | |
| CRP (mg/l) (overall range, 1.4–117.0; median, 5.8)F | ||||
| ≤ 6.0 | 30 | 54.5 | 4.39 (1.92) | NS |
| > 6.0 | 25 | 45.5 | 5.10 (1.75) | |