Table 1

Association of argyrophilic nucleolar organiser region (AgNOR) count with clinical and biological parameters at diagnosis

ParameterN%AgNOR count (mean (SD))Significance
*Cytoplasmic κ chain only.
†Overall range (median): serum IgG, 18.5–90.1 g/l (57.8); serum IgA, 10.5–61.8 g/l (28.65); urinary light chain, 2.4–13.7 g/24 hours (9.4).
‡IgG, ≤ 60 g/l; IgA, ≤ 40 g/l; urinary light chain ≤8 g/24 hours.
¶Total 53 (IgD and non-secretory patients not included).
FMean (SD) are not given for distributions significantly deviating from normal.
β2m, β2 microglobulin; CRP, C reactive protein; LDH, lactate dehydrogenase; NS, not significant.
Stage
I814.53.09 (1.19)p < 0.005
II916.43.80 (1.53)
III3869.15.28 (1.79)
Substage
A4887.34.73 (1.93)NS
B712.74.60 (1.42)
Heavy chain isotype
γ3563.64.79 (1.79)NS
α1425.53.99 (1.85)
δ11.87.3
Bence-Jones47.36.38 (1.55)
Non-secretory*11.83.2
Light chain isotype
κ3258.24.89 (1.87)NS
λ2341.84.50 (1.87)
Haemoglobin (g/l) (overall range, 68–160; median, 107, mean, 110.7; SD, 19.7)
≤ 1052647.35.16 (2.11)NS
> 1052952.74.32 (1.54)
Calcium (mg/l) (overall range, 78–127; median, 99; mean, 98.5; SD, 9.8)
≤ 1003665.54.47 (1.79)NS
> 1001934.55.19 (1.96)
Skeletal lesions scale
0916.43.91 (1.89)NS
147.34.48 (1.72)
21425.44.76 (1.95)
32850.94.99 (1.86)
M protein concentration†
Low‡34¶64.24.01 (1.52)p < 0.001
High1935.85.92 (1.80)
Platelet count (×109/l) (overall range, 75–340; median, 200)F
≤ 1501120.04.67 (1.46)NS
> 1504480.04.73 (1.97)
Albumin (g/l) (overall range, 21–48; median, 35; mean, 34.9; SD, 6.8)
≤ 301730.94.95 (1.85)NS
> 303869.14.61 (1.88)
LDH (U/l) (overall range, 52–854; median, 127)F
≤ 1804683.64.89 (1.82)NS
> 180916.44.31 (2.32)
Marrow infiltration rate (%) (overall range, 15–95; median, 50)F
≤ 301832.74.61 (1.37)NS
31–501527.33.81 (1.69)
> 502240.05.42 (2.10)
Histological grade
I2952.74.87 (1.78)NS
II1832.74.58 (1.88)
III814.64.46 (2.30)
β2m (mg/l) (overall range, 0.9–11.3; median, 3.0)F
≤ 6.03970.94.68 (1.83)NS
> 6.01629.14.80 (2.02)
CRP (mg/l) (overall range, 1.4–117.0; median, 5.8)F
≤ 6.03054.54.39 (1.92)NS
> 6.02545.55.10 (1.75)