Table 1

Indications for performing a trephine biopsy

Definite indications
Investigation of suspected Hodgkin's disease and non-Hodgkin's lymphoma
Staging of non-Hodgkin's lymphoma
Diagnosis and follow up of hairy cell leukaemia
Evaluation and follow up of chronic lymphocytic leukaemia
Diagnosis of suspected metastatic carcinoma
Diagnosis, staging, and follow up of small cell tumours of childhood
Investigation of suspected myeloproliferative disorders (polycythaemia rubra vera, essential thrombocythaemia, idiopathic myelofibrosis, and systemic mastocytosis)
Diagnosis of aplastic anaemia, hypoplastic myelodysplastic syndromes, and hypoplastic acute myeloid leukaemia
Investigation of an unexplained leucoerythroblastic blood film
Investigation of a fever of unknown origin
Investigation of suspected bone disease
Evaluation of any patient in whom an adequate bone marrow aspirate cannot be obtained
Investigation of patients in whom multiple myeloma is suspected and investigation of selected patients with serum paraproteins without other evidence of multiple myeloma
Possible indications
Investigation of suspected acute myeloid leukaemia
Investigation of suspected myelodysplastic syndrome
Staging of Hodgkin's disease
Evaluation of chronic myeloid (granulocytic) leukaemia
Investigation of suspected primary amyloidosis