Table 1

Clinical, morphological, and biological data of the entire study group T1–4 N0–2 M0 (n = 307)

p21waf negativep21waf positiveTotal
n%n%n% p Value
Univariate statistical calculation using χ2 test.
Receptor status: positive, ER positive and/or PR positive; negative, ER negative and PR negative; detection by immunohistochemistry.
Lymph nodes were removed in 295 cases, steroid hormone receptor status was determined in 302 women, PCNA in 301, Her2/neu expression in 298, and p53 expression in 299 samples.
ER, oestrogen receptor; NS, not significant; PCNA, proliferating cell nuclear antigen; PR, progesterone receptor.
Age (years)
    < 507323.83511.410835.2
    > 5013544.06420.819964.8NS
Menopausal status
    Pre5919.2289.18728.3
    Peri289.1165.24414.3
    Post12139.412139.417657.3NS
Tumour size (cm)
    < 28026.13511.411537.5
    > 2–510233.24514.714749.9
    > 5268.5196.24514.7NS
Nodal status
    N09030.54414.913445.4
    1–3 nodes6923.4279.29632.5
    > 4 nodes4013.6258.56522.0NS
Tumour grade
    GI3310.7175.55016.3
    GII11035.85317.316353.1
    GIII6521.2299.49430.6NS
Receptor status
    Negative6621.9278.99330.8
    Positive13946.07023.220969.2NS
PCNA
    < 10%9531.64113.613645.2
    10–49%7123.6268.69732.2
    > 50%3712.33110.36822.60.029
Her2/neu
    Negative15351.37926.523277.9
    Positive4916.4175.76622.1NS
p53
    Negative12341.15719.118060.2
    Positive8127.13812.711939.8NS
p21waf20867.89932.2