Table 2

Clinical, morphological, and biological data of node negative women T1–4 N0 M0 (n = 134)

p21waf negativep21waf positiveTotal
n%n%n% p Value
Univariate statistical calculation using χ2 test.
Receptor status: positive, ER positive and/or PR positive; negative, ER negative and PR negative; detection by immunohistochemistry.
Steroid hormone receptor status was determined in 132 women, PCNA in 131, Her2/neu expression in 130, and p53 expression in 131 samples.
ER, oestrogen receptor; NS, not significant; PCNA, proliferating cell nuclear antigen; PR, progesterone receptor.
Age (years)
   < 50 years3425.4139.74735.1
    > 505641.83123.18764.9NS
Menopausal status
    Pre2518.7107.53526.1
    Peri1410.475.22115.7
    Post5138.12720.17858.2NS
Tumour size (cm)
    < 24835.81712.76548.5
    2–54130.61914.26044.8
    > 510.786.096.70.001
Tumour grade
    GI1511.2107.52518.7
    GII5339.62115.77455.2
    GIII2216.4139.73526.1NS
Receptor status
    Negative2518.9139.83828.8
    Positive6347.73123.59471.2NS
PCNA
    < 10%4534.42015.36549.6
    10–49%3325.2118.44433.6
    > 50%96.9139.92216.80.017
Her2/neu
    Negative6751.53728.510480.0
    Positive2015.464.62620.0NS
p53
    Negative5945.02619.88564.9
    Positive3022.91612.24635.1NS
p21waf9067.24432.8