Correlation between AP-2α, AP-2β, AP-2γ, and AP-2α ISH and Dukes's classification and histological grade
| Dukes's classification | |||||
|---|---|---|---|---|---|
| A (n) | B (n) | C (n) | D (n) | ||
| AP-2α | |||||
| <10% | 1 | 1 | 8 | 5 | χ2 = 10.4 |
| ≥10% | 3 | 8 | 3 | 1 | p = 0.02 |
| AP-2β | |||||
| <45% | 1 | 5 | 4 | 5 | χ2 = 1.76 |
| ≥45% | 3 | 4 | 7 | 1 | p = 0.19 |
| AP-2γ | |||||
| <15% | 2 | 3 | 5 | 5 | χ2 = 1.75 |
| ≥15% | 2 | 6 | 6 | 1 | p = 0.19 |
| AP-2α ISH | |||||
| −/+ | 3 | 4 | 3 | 3 | χ2 = 2.9 |
| ++/+++ | 1 | 5 | 8 | 3 | p = 0.40 |
| Histological grade | ||||
|---|---|---|---|---|
| 1 (n) | 2 (n) | 3 (n) | ||
| Percentages are the 50th centiles in a frequency distribution. | ||||
| −/+, negative/focally positive; ++/+++, diffusely positive (++, moderate; +++, strong). | ||||
| ISH, in situ hybridisation. | ||||
| AP-2α | ||||
| <10% | 3 | 7 | 5 | χ2 = 6.04 |
| ≥10% | 5 | 10 | p = 0.04 | |
| AP-2β | ||||
| <45% | 2 | 10 | 3 | χ2 = 1.9 |
| ≥45% | 6 | 7 | 2 | p = 0.17 |
| AP-2γ | ||||
| <15% | 1 | 10 | 4 | χ2 = 6.17 |
| ≥15% | 7 | 7 | 1 | p = 0.01 |
| AP-2α ISH | ||||
| −/+ | 5 | 8 | 0 | χ2 = 4.24 |
| ++/+++ | 3 | 9 | 5 | p = 0.04 |