Table 3

Definitions of cytomegalovirus (CMV) disease38

DiseaseDefinition
BAL, bronchial lavage fluid; CNS, central nervous system; CSF, cerebrospinal fluid.
Pneumonia (transplant recipients)Radiographic changes and/or hypoxia.
CMV detected in BAL or lung biopsy
Pneumonia (HIV infected patients)Symptoms of pneumonia with hypoxaemia.
CMV detected in the lung.
Absence of other pathogens
GastrointestinalGastrointestinal symptoms with CMV detected by histology
HepatitisAbnormal liver function tests coupled with histological changes and CMV detection in a liver biopsy by culture, histology, or DNA hybridisation
NeurologicalSymptoms of encephalitis, transverse myelitis, or other CNS symptoms, plus CMV in the CSF by culture or PCR
RetinitisTypical ophthalmological lesions without virological proof