Immunopathological results of colonic biopsies in cryptosporidiosis and controls
| Cryptosporidiosis (group I) | AIDS without intestinal infection (group II) | Control (group III) | |
|---|---|---|---|
| Phenotypic analysis of infiltrating lymphoid cells within the lamina propria and surface epithelium. Values are expressed as percentage of cells of phenotype shown as a subset of all nucleated cells within six representative grids (lamina propria) or cells of phenotype/100 epithelial cells (surface epithelium). | |||
| Values are means (SE) of samples. | |||
| Cryptosporidiosis v HIV negative controls: *, p <0.001; **, p <0.00001. | |||
| Cryptosporidiosis v AIDS without intestinal infection: §, p <0.05; §§, p <0.01; §§§, p <0.0001. | |||
| AIDS without intestinal infection v controls: #, p <0.05; ##, p <0.001. | |||
| HLA-DR, human major histocompatibility complex DR antigen; IELs: intraepithelial lymphocytes. | |||
| Number of biopsies | 10 | 9 | 9 |
| IELs | |||
| CD3 | 6.1 (2.9) | 10.7 (3.8) | 8.2 (5.1) |
| CD8 | 3.5 (1.8) | 5.5 (4.3) | 5.3 (3.2) |
| TiA1 | 6.9 (4.6) | 9.7 (2.9) | 6.6 (3.6) |
| Lamina propria | |||
| CD3 | 23.8 (4.8) | 20.4 (7.9) | 15.2 (1.3)* |
| CD8 | 22.1 (2.8)§ | 15.2 (6.7)# | 7.9 (1.4)** |
| TiA1 | 23.8 (5.1)§§ | 16.9 (4.7)## | 7.7 (2.8)** |
| Granzyme B | 8.7 (2.6)§§§ | 2.2 (2.4)# | 0.2 (0.4)** |
| CD68 | 34.9 (4.8) | 32.8 (6.7) | 30.6 (6.6) |
| Glandular expression of HLA-DR (/10 glands) | 6.8 (2.3)§ | 2.4 (4.3) | 0 |