Table 4

Disease sensitivity, specificity, and positive predictive value (PPV) of various methods for the analysis of Ro, La, Sm, and U1-RNP for a diagnosis of systemic lupus erythematosus^9,^10,^12,^13,^16,^28,³²^–³⁶

Anti-Ro	Sensitivity	Specificity	PPV
All figures expressed as percentages.
CIE, countercurrent immunoelectrophoresis; ELISA, enzyme linked immunosorbent assay; RNP, ribonuclear protein.
Double diffusion	33	97	84
CIE	29	99	64
ELISA (in house)	55	85	59
ELISA (commercial)	61	80–93	75–91
Anti-La
Double diffusion	15	99	90
CIE	14	99	81
ELISA (in house)	24	85	39
ELISA (commercial)	27–35	88–97	73–90
Anti-Sm
Double diffusion	17–35	99–100	89–100
CIE	11–56	98–100	90–100
ELISA (in house)	19–33	87–100	12–100
ELISA (commercial)	34–45	88–100	73–100
Anti-U1-RNP
Double diffusion	17–30	87–99	31–90
CIE	8–35	83–99	37–57
ELISA (in house)	4–46	91–98	11–67
ELISA (commercial)	39–64	84–97	70–95