Table 1

Clinicopathological results

BRCA1− (n = 38)
BRCA1+(n = 7)Familial cases(n = 16)Sporadic cases(n = 22)
Oestrogen receptor status was studied by enzyme immunoanalysis.
Group at risk (family history)
High risk710
Low risk06
Age at diagnosis (years)
≤455614
>452108
Tumour size (cm)
T1 (≤2)388
T2 (2–5)4410
T3 (≥5)044
TNM stage
I284
II537
III0511
Histological type (WHO)
Invasive ductal carcinoma31219
Medullary carcinoma413
Invasive lobular carcinoma020
Mucinous carcinoma010
Histological grade (Bloom and Richardson, Nottingham)
Grade I077
Grade II2712
Grade III523
Axillary lymph node status
Positive1513
Negative6119
Oestrogen receptor
Positive (≥10 fmol/mg)1616
Negative (< 10 fmol/mg)6106
Overall free survival (years)
≤54914
>5378