Table 1

Overlap syndromes in autoimmune rheumatic disease and associated autoantibodies78

Overlap syndromeAutoantibody directed to
hnRNP, heterogeneous nuclear ribonuclear protein; PM-Scl, polymyositis-scleroderma overlap syndrome.
Mixed connective tissue diseasenRNP; hnRNP(A2/RA33 complex); U1 RNA
tRNA synthetase syndromeJo-1, PL-7, PL-12, OJ, EJ
Polymyositis/pulmonary fibrosisKJ
Polymyositis/systemic lupus erythematosus56 kDa nRNP
Polymyositis/sclerodermaKu; PM-Scl; U2 RNP; DNA-PK
Secondary Sjögren's syndromeRo/SSA; La/SSB; Ki/SL
Rheumatoid arthritis/systemic lupus erythematosusNone identified
Scleroderma (CREST)/primary biliary cirrhosisCentromere; pyruvate dehydrogenase complex
Systemic lupus erythematosus/autoimmune hepatitistRNA