Table 1

MSI and MMR gene mutation status and MLH1 and MSH2 protein expression in the 46 colorectal cancers studied

PatientMSI statusGermline mutationMLH1 expressionMSH2 expression
*MLH1 exon 6, codon 175, 10 bp deletion; †MLH1 exon 19, codon 753, T deletion; ‡MLH1 exon 13, codon (CGA to TGA ) 487 stop; ¶MLH1 exon 17, codon 646, AG insertion.
MMR, DNA mismatch repair; MSI, microsatellite instability.
2142++*–+
4046+––+
2140+–+–
4020+–+–
4002+––+
2055+––+
2112+––+
2217+–++
4088++†–+
2181+––+
2047+––+
2088+––+
2065+––+
2185+–+–
2204++‡–+
2137+–+–
140+––+
2183+––+
331++¶–+
4094+–+–
82+––+
70+––+
4171+––+
2020–++
2045–++
2090–++
2196–++
2127–++
2109–++
2154–++
409–++
386–++
382–++
337–++
88–++
2174–++
2205–++
4053–++
2193–++
2209–++
2091–++
2015–++
2037–++
2085–++
2084–++
2201–++