Table 2

Treatment induced morphological changes in tumour cells

Tumour characteristicsMorphology after chemoradiotherapy
ArchitectureDissociated tubules, short lines, or single cells in a fibrotic stroma. In mucinous tumours, cells were discohesive and suspended in pools of mucin
NucleusVery large and bizarrely shaped with multiple lobes and a “popcorn”-like appearance. Chromatin was vesicular. Nucleoli were large and often multiple
CytoplasmDense, granular, and eosinophilic or vacuolated. There was merging of cytoplasm of adjacent cells