Treatment induced morphological changes in tumour cells
| Tumour characteristics | Morphology after chemoradiotherapy |
|---|---|
| Architecture | Dissociated tubules, short lines, or single cells in a fibrotic stroma. In mucinous tumours, cells were discohesive and suspended in pools of mucin |
| Nucleus | Very large and bizarrely shaped with multiple lobes and a “popcorn”-like appearance. Chromatin was vesicular. Nucleoli were large and often multiple |
| Cytoplasm | Dense, granular, and eosinophilic or vacuolated. There was merging of cytoplasm of adjacent cells |