Quantitative analysis data and comparison between the extent of apoptosis in normal alveoli and remodelled areas and the proportion of apoptotic type II pneumocyte nuclei in these areas in sections of lung from patients with IPF/UIP
| Extent of areas with apoptotic nuclei of section (%) | Proportion of apoptotic nuclei in positive areas of section (%) | |||
|---|---|---|---|---|
| Patient | Normal | Remodelled | Normal | Remodelled |
| CV, coefficient of variation; IPF, idiopathic pulmonary fibrosis; UIP, usual interstitial pneumonia. | ||||
| 1 | 15.3 | 5.0 | 14.0 | 3.0 |
| 2 | 20.0 | 2.03 | 19.0 | 3.0 |
| 3 | 50.0 | 7.08 | 30.0 | 2.0 |
| 4 | 45.0 | 4.8 | 18.0 | 1.9 |
| 5 | 10.0 | 0.0 | 29.0 | 0.0 |
| 6 | 15.0 | 3.8 | 20.0 | 2.9 |
| 7 | 25.0 | 5.0 | 35.0 | 3.4 |
| 8 | 50.0 | 6.6 | 28.0 | 2.0 |
| 9 | 30.0 | 9.0 | 23.0 | 5.0 |
| 10 | 10.0 | 0.0 | 18.0 | 0.0 |
| 11 | 50.0 | 11.0 | 35.0 | 8.7 |
| 12 | 50.1 | 12.0 | 32.0 | 6.7 |
| 13 | 10.0 | 1.9 | 18.0 | 2.0 |
| 14 | 0.0 | 0.0 | 0.0 | 0.0 |
| 15 | 45.0 | 9.0 | 30.0 | 5.7 |
| 16 | 50.0 | 13.0 | 30.0 | 8.9 |
| 17 | 50.0 | 6.6 | 28.0 | 5.4 |
| 18 | 25.1 | 3.5 | 32.0 | 7.6 |
| 19 | 0.0 | 0.0 | 0.0 | 0.0 |
| Patients (total) | 19 | |||
| Mean (SEM) | 28.9 (4.3) | 5.4 (0.9) | 24.1 (2.0) | 3.3 (0.6) |
| CV between groups | 33.6 | 37.7 | 36.0 | 40.2 |
| CV within groups | 30.1 | 24.0 | 26.1 | 18.2 |
| p Value | 0.0001 | 0.0001 | ||