Inclusion and exclusion criteria for quantitative pathological analysis of Barrett’s biopsies (after Sandick et al, 2000,13 with modifications)
| Inclusion criteria |
| 1 Biopsies with Barrett’s mucosa AND |
| 2 Presence of homogeneous area of no dysplasia, low grade dysplasia or high grade dysplasia in 5 or more well oriented glands AND |
| 3 Biopsies with full thickness mucosa including the muscularis mucosae |
| Exclusion criteria |
| 1 Biopsies showing severe endoscopy induced mechanical distortion (crushing, smearing) AND/OR |
| 2 Biopsies with a sole area of glandular epithelium immediately adjacent to the squamo–columnar junction AND/OR |
| 3 Severe inflammation AND/OR |
| 4 Extensive ulceration AND/OR |
| 5 Any doubt as to the applicability or fulfilment of the inclusion criteria AND/OR |
| 6 Any doubt as to the adequacy of the Ki67 stain AND/OR |
| 7 Too bleach Ki67 stain |