Table 3

The various morphological, morphometric, immunohistochemical, and molecular biological findings in AAH and adenocarcinoma

Low grade AAHHigh grade AAHAdenocarcinoma (including BAC)
AAH, atypical adenomatous hyperplasia; AgNOR, silver stained nucleolar organising region; BAC, bronchioloalveolar cell carcinoma; CEA, carcinoembryonic antigen; LOH, loss of heterozygosity.
Cellularity and atypia++++++
Mean nuclear area++++++
Nuclear DNA content+++++
AgNOR count++++++
CEA, p450, ApoA expression+++++
p53 expression++++++
K-ras mutation−/++++
C-erb-B2 expression+++
Loss of Rb and p16+
3p, 7p, 17p/q LOH+++
Blood group antigen expression+++++
Cyclin D1 overexpression++++++