Low grade AAH | High grade AAH | Adenocarcinoma (including BAC) | |
---|---|---|---|
AAH, atypical adenomatous hyperplasia; AgNOR, silver stained nucleolar organising region; BAC, bronchioloalveolar cell carcinoma; CEA, carcinoembryonic antigen; LOH, loss of heterozygosity. | |||
Cellularity and atypia | + | ++ | +++ |
Mean nuclear area | + | ++ | +++ |
Nuclear DNA content | + | ++ | ++ |
Aneuploidy | + | ++ | ++ |
AgNOR count | + | ++ | +++ |
CEA, p450, ApoA expression | + | ++ | ++ |
p53 expression | + | ++ | +++ |
K-ras mutation | −/+ | + | ++ |
C-erb-B2 expression | + | ++ | |
Loss of Rb and p16 | + | ||
3p, 7p, 17p/q LOH | + | ++ | |
Blood group antigen expression | +++ | + | + |
Cyclin D1 overexpression | +++ | ++ | + |