Table 3

The performance of human papillomavirus (HPV) detection and cervical cytology by Papanicolaou (Pap) smear and lavages taken by the doctor and the patient for the detection of high grade cervical intraepithelial neoplasia (CIN)

		CIN 2 or 3
Test	Test result	Yes (n)	No (n)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
*All women with abnormal cervical cytology underwent colposcopic examination and biopsy sampling. Differences in the performance of the tests were calculated. Mc-Nemar cytology smear versus lavage taken by doctor: χ²=10.1; p< 0.001; cytology lavage taken by doctor versus lavage taken by patient: χ²=0.2; NS; cytology smear versus lavage taken by patient: χ²=13.1; p< 0.001. HR-HPV testing smear versus lavage taken by doctor: χ²=0; NS; HR-HPV testing lavage taken by doctor versus lavage taken by patient: χ²=1.3; NS; HR-HPV testing smear versus lavage taken by patient: χ²=1.3; NS. HR, high risk; NPV, negative predictive value; NS, not significant; PPV, positive predictive value.
Cervical cytology
Pap smear (n=71)	Normal (n=15)	–	15	100*	40	59	100*
	Very mild dyskaryosis (n=5)	3	2
	Mild dyskaryosis (n=11)	3	8
	≥Moderate dyskaryosis (n=46)	27	13

Lavage taken by doctor (n=71)	Normal (n=42)	12	30	61	81	73	71
	Very mild dyskaryosis (n=3)	1	2
	Mild dyskaryosis (n=6)	3	3
	≥Moderate dyskaryosis (n=17)	15	2
	Unsatisfactory	2	1

Lavage taken by patient (n=71)	Normal (n=43)	15	28	42	93	85	65
	Very mild dyskaryosis (n=1)	1	–
	Mild dyskaryosis (n=1)	1	–
	≥Moderate dyskaryosis (n=11)	9	2
	Unsatisfactory	–	–
	Not done	7	8

HPV testing
Pap smear (n=71)	HR-HPV + (n=52)	30	22	91	42	58	84
	HR-HPV – (n=19)	3	16
	β Globin negative	–	–

Lavage taken by doctor (n=71)	HR-HPV + (n=50)	29	21	91	43	58	84
	HR-HPV – (n=19)	3	16
	β Globin negative	1	1

Lavage taken by patient (n=71)	HR-HPV + (n=30)	21	9	81	68	70	79
	HR-HPV– (n=24)	5	19
	β Globin negative	–	2
	Not done	7	8